Impairment of Glucose Tolerance Over 10 Years in Middle-Aged Normal Glucose Tolerant Indians
- Chittaranjan S. Yajnik, MD1,
- Kishore M. Shelgikar, MD1,
- Sadanand S. Naik, PHD1,
- Mehmood G. Sayyad, MSC1,
- Kondiram N. Raut, MSW1,
- Dattatraya S. Bhat, MSC1,
- Jyoti A. Deshpande, MSC1,
- Shailaja D. Kale, MD1 and
- Derek Hockaday, FRCP2
- 1Diabetes Unit, KEM Hospital and Research Centre, Pune, India
- 2Oxford Lipid Metabolism Unit, Sheikh Rashid Laboratories, Radcliffe Infirmary, Oxford, U.K
- Address correspondence to Chittaranjan S. Yajnik, MD, Diabetes Unit, KEM Hospital and Research Centre, Rasta Peth, Pune 411011, India. E-mail: diabetes{at}vsnl.com
We followed 191 normal glucose tolerant (NGT; 1985 World Health Organization criteria) nondiabetic subjects (115 men) as control subjects in the Wellcome Diabetes Study (1). Their mean age was 41 years (SD 11.2), BMI 23.6 kg/m2 (34% >25 kg/m2), and 31% had a first-degree relative with diabetes.
During the next 10 years, 8 (7 men) died, 40 were lost to follow up, 14 men and 8 women became impaired glucose tolerant (IGT), and 2 men and 4 women developed diabetes. Men whose glucose tolerance deteriorated were heavier at entry …
