Clinical and Genetic Heterogeneity of Latent Autoimmune Diabetes in Adults
- Michiaki Fukui, MD1,
- Yoshihiro Kitagawa, MD1,
- Naoto Nakamura, MD2 and
- Toshikazu Yoshikawa, MD2
- 1Department of Endocrinology and Hematology, Osaka General Hospital of West Japan Railway Company, Osaka, Japan
- 2First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
- Address correspondence to Michiaki Fukui, MD, The Department of Endocrinology and Hematology, Osaka General Hospital of West Japan Railway Company, 1-2-22 Matsuzaki-cho, Abeno-ku, Osaka 545-0053, Japan. E-mail: sayarinapm{at}hotmail.com.
We read with great interest the recent article by Hosszufalusi et al. (1) reporting that latent autoimmune diabetes in adults (LADA) manifests clinical features similar to those of adult-onset type 1 diabetes with rapid progression, and that prevalences of predisposing alleles and haplotypes did not differ between these two forms of autoimmune diabetes. Patients with LADA have been found to be heterogeneous in their clinical attributes (2). Some patients develop insulin deficiency within a few years (LADA-type 1), while others show clinical and metabolic markers similar to patterns in antibody-negative type 2 diabetes (LADA-type 2). As the authors noted, selection …
