Management of Uncontrolled Hypertension in a Nurse-Led Clinic Compared With Conventional Care for Patients with Type 2 Diabetes

  1. Elizabeth A. Denver, RN1,
  2. Maria Barnard, BSC, MBCHB, FRCP2,
  3. Robin G. Woolfson, MD, FRCP2 and
  4. Kenneth A. Earle, MD, FRCP1
  1. 1Royal Free and University College London Medical School, Whittington Hospital, London, U.K.
  2. 2Whittington Hospital NHS Trust, Department of Diabetes and Endocrinology, London, U.K.
  1. Address correspondence and reprint requests to Dr. K.A. Earle, St. George’s Hospital, Thomas Addison Diabetes Centre, Lanesborough Wing, Blackshaw Road, London SW17 ORE, U.K. E-mail: ken.earle{at}


OBJECTIVE—To compare the effectiveness of a nurse-led hypertension clinic with conventional community care in general practice in the management of uncontrolled hypertension in patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS—We studied 120 men and women outpatient attendees (61% non-Caucasian) with type 2 diabetes and a seated blood pressure (BP) ≥140/80 mmHg. All patients were being treated for hypertension, and 71% had increased urinary albumin excretion (UAE). Patients were allocated to either a nurse-led hypertension clinic or conventional primary care. The primary outcome measure was a change in systolic BP. Secondary outcome measures were total cholesterol, HDL cholesterol, total triglycerides, HbA1c, UAE, serum creatinine, and changes in absolute stroke and coronary heart disease (CHD) risk scores.

RESULTS—The mean (95% CI) difference in the decrement of systolic BP was 12.6 mmHg (5.9–19.3) (P = 0.000) in favor of the nurse-led group, whose patients were three times more likely to a reach target systolic BP <140 mmHg compared with conventional care (P = 0.003). A significant fall in 10-year CHD (P = 0.004) and stroke risk (P = 0.000) scores occurred only in the nurse-led group. There were no significant differences in the reduction of diastolic BP or any of the other secondary outcome measures at 6 months.

CONCLUSIONS—Compared with conventional care, a nurse-led hypertension clinic is a more effective intervention for patients with type 2 diabetes and uncontrolled hypertension. A target systolic BP <140 mmHg is more readily achieved and may be associated with significant reductions in 10-year cardiovascular disease risk scores.


  • A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

    • Accepted May 12, 2003.
    • Received February 11, 2003.
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