Interactions Between Peroxisome Proliferator–Activated Receptor Gene Polymorphism and Birth Length Influence Risk for Type 2 Diabetes
- Johan G. Eriksson, MD, PHD1,
- Clive Osmond, PHD1,
- Virpi Lindi, MSC2,
- Matti Uusitupa, MD, PHD2,
- Tom Forsen, MD, PHD1,
- Markku Laakso, MD, PHD3 and
- David Barker, FRC1
- 1MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, U.K.
- 2Department of Medicine, University of Kuopio, Kuopio, Finland
- 3Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Helsinki, Finland
- Address correspondence to Johan G. Eriksson, National Public Health Institute, Department of Epidemiology and Health Promotion, Mannerheimintie 166, FIN-00300 Helsinki, Finland. E-mail: johan.eriksson{at}ktl.fi
Type 2 diabetes has previously been shown to be associated with a small body size at birth, which is considered an indicator of the intrauterine environment. This inverse association has been observed between both birth weight and birth length (1,2). The peroxisome proliferator–activated receptor (PPAR) γ2 gene is associated with glucose and lipid metabolism and is therefore a major candidate gene for type 2 diabetes (3,4). We have previously reported that the effects of the Pro12Pro genotype of the PPAR γ2 gene on insulin sensitivity depends on birth size (5). In …
