High Frequency of Type 1B (Idiopathic) Diabetes in North Indian Children With Recent-Onset Diabetes
- Krishnamurthy Balasubramanian, MD, DM1,
- Preeti Dabadghao, MD, DM1,
- Vijayalakshmi Bhatia, MD1,
- Peter G. Colman, MD2,
- Shane A. Gellert, BS2,
- Udalak Bharadwaj, PHD3,
- Suraksha Agrawal, PHD3,
- Nalini Shah, MD, DM4 and
- Eesh Bhatia, MD1
- 1Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
- 2Department of Diabetes and Endocrinology, Royal Melbourne Hospital, Victoria, Australia
- 3Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
- 4Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, India
- Address correspondence to Eesh Bhatia, MD, Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India. E-mail: ebhatia{at}sgpgi.ac.in
Islet antibody–negative or type 1B (idiopathic) diabetes constitutes 5–10% of Caucasian diabetic subjects with recent-onset type 1 diabetes (1). A study from Italy (2) failed to show clinical differences between these patients and those with antibodies. In contrast, a fulminant form of type 1B diabetes with associated exocrine pancreatic involvement, possibly secondary to viral infection, has been described in Japanese (3). There is little information on type 1B diabetes in other racial groups. Therefore, we studied the frequency and characteristics of type 1B diabetes in children of north Indian origin.
We studied all 55 children (32 male and 23 female) with recent-onset type 1 diabetes who presented at our diabetes clinic over a 10-year period. Subjects had …
