Plasma Adiponectin and Pregnancy-Induced Insulin Resistance

  1. Károly Cseh, MD, DSC1,
  2. Éva Baranyi, MD, PHD2,
  3. Zsolt Melczer, MD3,
  4. Edit Kaszás, MD1,
  5. Éva Palik, MD4 and
  6. Gábor Winkler, MD, DSC5
  1. 11st Department of Internal Medicine, Károlyi Hospital, Budapest, Hungary
  2. 2National Health Center Diabetes Outpatient Unit, Budapest, Hungary
  3. 32nd Department of Obstetrics and Gynecology, Budapest, Hungary
  4. 43rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
  5. 5Department of Internal Medicine II, St. John’s Hospital, Budapest, Hungary
  1. Address correspondence to Gábor Winkler, MD, DSc, Head of the Department of Internal Medicine II, St. John’s Hospital, Budapest, Diós árok 1-3, Hungary. E-mail: winkler.gabor{at}

Lindsay et al. (1) recently published an article in Diabetes Care that claims adiponectin is present in the cord blood of the offspring of diabetic and nondiabetic pregnant mothers and that its level does not correlate with their birth weight and skinfold thickness. Our data, obtained from a case-control study of nondiabetic women and women with gestational diabetes mellitus (GDM), further support the role of adiponectin in insulin resistance.

We observed significantly decreased plasma adiponectin levels (7.55 ± 2.04 μg/ml [means ± SD]) using radioimmunoassay (Linco Research, St. Charles, MO) (intra-assay precision coefficient of variation [CV] 3.86%, interassay CV 8.47%) in 30 women with GDM, all of whom were treated with insulin (aged 28.12 ± 2.71 years, gestational age 27.35 ± 6.15 weeks), compared with 40 nondiabetic pregnant women tested with oral glucose tolerance test (OGTT) (total group 9.91 ± 3.32, P < 0.01, Mann-Whitney, aged 26.91 ± 2.65 years, gestational age …

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