Comparative Study of Prognostic Value for Coronary Disease Risk Between the U.K. Prospective Diabetes Study and Framingham Models
- Ioannis D. Protopsaltis, MD, PHD,
- Panayiotis A. Konstantinopoulos, MD,
- Alexandros V. Kamaratos, MD, PHD and
- Andreas I. Melidonis, MD, PHD
- From the Diabetes Center, Tzaneio General Hospital of Piraeus, Piraeus, Greece
- Address correspondence to Dr. Ioannis D. Protopsaltis, Tzaneio General Hospital of Piraeus, Diabetes Center, Zanni & Afentouli 1, Piraeus, 185 36, Greece. E-mail: tzaniodiabetes{at}yahoo.com
According to epidemiological and angiographic studies (1,2), diabetic patients present a two to four times greater risk for coronary artery disease (CAD) than nondiabetic individuals.
The Framingham model (3) estimates 10-year CAD risk based on the traditional risk factors, including age, sex, HDL and LDL cholesterol, hypertension, and smoking. In addition to these risk factors, the U.K. Prospective Diabetes Study (UKPDS) model, designed for people with type 2 diabetes (4), incorporates more specific variables, such as HbA1c, age at diabetes diagnosis, and diabetes duration.
The aim of this analysis was to compare the accuracy of these models in the prediction of 10-year risk for CAD in diabetic patients.
Clinical information related to the above factors was retrieved …
