Non-HDL Cholesterol Contributes to the “Hypertriglyceridemic Waist” as a Cardiovascular Risk Factor
The Hoorn Study
- Griët Bos, MSC1,
- Jacqueline M. Dekker, PHD1 and
- Robert J. Heine, PHD12
- 1Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, the Netherlands
- 2Department of Endocrinology, Diabetes Center, VU University Medical Center, Amsterdam, the Netherlands
- Address correspondence to G. Bos, MSc, Institute for Research in Extramural Medicine, VU University Medical Center Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands. E-mail: g.bos.emgo{at}med.vu.nl
Lemieux et al. (1) described the “hypertriglyceridemic waist” as a marker of the atherogenic metabolic triad (hyperinsulinemia, hyperapolipoprotein B, and small, dense LDL) in men. In 287 men, those with a waist circumference ≥90 cm and with triglyceride levels ≥2 mmol/l had an odds ratio of 3.6 (95% CI 1.17–10.93) for having angiographically diagnosed coronary artery disease compared with those with smaller waists and lower triglyceride concentrations. We recently reported (2) the predictive value of non-HDL cholesterol and triglyceride concentrations for 10-year cardiovascular disease incidence in the Hoorn Study, a population-based cohort study of glucose tolerance. …
