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Phenotypic Heterogeneity and Associations of Two Aldose Reductase Gene Polymorphisms With Nephropathy and Retinopathy in Type 2 Diabetes

Response to Ng et al.

  1. Juliana Chan, MD, FRCP and
  2. Ying Wang, PHD
  1. From the Department of Medicine and Therapeutics, the Chinese University of Hong Kong, the Prince of Wales Hospital, Shatin, Hong Kong
  1. Address correspondence to Juliana Chan, MD, FRCP, The Chinese University of Hong Kong, Department of Medicine & Therapeutics, Prince of Wales Hospital, Shatin, N.T., Hong Kong. E-mail: jchan{at}cuhk.edu.hk

We thank Ng et al. (1) for their response to our recent article on the associations of two aldose reductase gene polymorphisms, a (CA)n microsatellite at the 5′ region and a promoter C/T polymorphism with nephropathy and retinopathy in type 2 diabetes (2).

However, we hold the view that Ng et al. have misinterpreted our data …

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