Biological Variation in HbA1c Predicts Risk of Retinopathy and Nephropathy in Type 1 Diabetes
Response to Twomey et al.
- Stuart A. Chalew, MD1,
- Robert J. McCarter, SCD2 and
- James M. Hempe, PHD3
- 1Department of Endocrinology, Children’s Hospital, New Orleans, Louisiana
- 2Department of Bioinforatics and Statistics, Children’s National Medical Center, Washington, D.C
- 3Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, Louisiana
- Address correspondence to Stuart A. Chalew, MD, Children’s Hospital, Department of Endocrinology, 200 Henry Clay Ave., New Orleans, LA 70118. E-mail: schale{at}lsuhsc.edu
We appreciate the comments of Twomey et.al. (1) in regard to our recent article (2) about biological variation in HbA1c and its relationship to microvascular complications. They point out potential obstacles to the general use of the hemoglobin glycation index (HGI) by clinical practitioners. The best approach to calculating the HGI of individual patients from …
