Radial Artery Tonometry Demonstrates Arterial Stiffness in Children With Type 1 Diabetes
- Michael J. Haller, MD1,
- Margaret Samyn, MD2,
- Wilmer W. Nichols, PHD3,
- Todd Brusko, MD4,
- Clive Wasserfall, MS4,
- R. Fletcher Schwartz, BS4,
- Mark Atkinson, PHD4,
- Jonathan J. Shuster, PHD5,
- Gary L. Pierce, MS6 and
- Janet H. Silverstein, MD1
- 1Division of Pediatric Endocrinology, Department of Pediatrics, University of Florida, Gainesville, Florida
- 2Division of Pediatric Cardiology, Department of Pediatrics, University of Florida, Gainesville, Florida
- 3Division of Cardiology, Department of Medicine, University of Florida, Gainesville, Florida
- 4Department of Pathology, University of Florida, Gainesville, Florida
- 5General Clinical Research Center, University of Florida, Gainesville, Florida
- 6Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida
- Address correspondence and reprint requests to Michael J. Haller, MD, Pediatric Endocrinology, P.O. Box 100296, Gainesville, FL 32610. E-mail: hallemj{at}peds.ufl.edu
Abstract
OBJECTIVE—To determine if children with type 1 diabetes have increased arterial stiffness by estimating augmentation index with the simple noninvasive technique of radial artery tonometry.
RESEARCH DESIGN AND METHODS—We studied 98 type 1 diabetic children and 57 healthy control subjects, ages 10–18 years, matched for age, sex, race, and BMI, generating 43 matched pairs. Radial artery tonometry was performed, and blood was collected for analysis of fasting lipids, HbA1c, glucose, and cytokines in all children.
RESULTS—Children with diabetes had a significantly higher augmentation index corrected to a heart rate of 75 (AI75) than their matched control subjects. Mean AI75 in type 1 diabetic subjects was 1.11 ± 10.15 versus −3.32 ± 10.36 in control subjects. The case-control difference was 5.20 ± 11.02 (P = 0.0031).
CONCLUSIONS—Children with type 1 diabetes have increased arterial stiffness compared with healthy control subjects. Radial artery tonometry is a simple noninvasive technique that could be added to the armamentarium of tests used to provide cardiovascular risk stratification in children with type 1 diabetes.
- AI, augmentation index
- AI75, augmentation index corrected to a heart rate of 75
- hsCRP, high-sensitivity C-reactive protein
- IL, interleukin
- IMT, intima-medial thickness
Footnotes
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A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.
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- Accepted August 28, 2004.
- Received June 10, 2004.
- DIABETES CARE
