High Glucose Levels Induce an Increase in Membrane Antioxidants, in Terms of Vitamin E and Coenzyme Q10, in Children and Adolescents With Type 1 Diabetes
- Silvana Salardi, MD1,
- Stefano Zucchini, MD1,
- Daniela Elleri, MD1,
- Gabriele Grossi, MC2,
- Alberto M. Bargossi, AM, MD2,
- Stefano Gualandi, PHD1,
- Roberta Santoni, MD1,
- Alessandro Cicognani, MD1 and
- Emanuele Cacciari, MD1
- 1Department of Pediatrics, University of Bologna, Bologna, Italy
- 2Central Laboratory of “S.Orsola-Malpighi” Hospital, Bologna, Italy
- Address correspondence to Prof. Silvana Salardi, Department of Pediatrics, Via Massarenti 11, 40138 Bologna, Italy. E-mail: salardi{at}med.unibo.it
Oxidative stress is defined as an imbalance between prooxidants and antioxidants in favor of the former (1), and diabetic patients are considered a risk group for increased oxidative stress (2,3). Studies regarding oxidant/antioxidant balance in type 1 diabetic children and adolescents have given conflicting results (4–7). The aim of this study was to determine whether serum hydroperoxides (reactive oxygen metabolites [ROMs]) as oxidative markers and plasma α-tocopherol (vitamin E) and coenzyme Q10 as indexes of antioxidant capacity could be related to metabolic control in 75 unselected children, adolescents, and young adults with type 1 diabetes. ROMs are the first markers of oxidation and one of the most reliable indicators of oxidative stress. Vitamin E is an important chain-breaking …
