Increased Oxidative Stress Is Associated With Serum Levels of Triglyceride, Insulin Resistance, and Hyperinsulinemia in Japanese Metabolically Obese, Normal-Weight Men
- Akira Katsuki, MD1,
- Yasuhiro Sumida, MD1,
- Hideki Urakawa, MD1,
- Esteban C. Gabazza, MD1,
- Shuichi Murashima, MD2,
- Kaname Nakatani, MD3,
- Yutaka Yano, MD1 and
- Yukihiko Adachi, MD1
- 1Third Department of Internal Medicine, Mie University School of Medicine, Mie, Japan
- 2Department of Radiology, Mie University School of Medicine, Mie, Japan
- 3Department of Laboratory Medicine, Mie University School of Medicine, Mie, Japan
- Address correspondence to Y. Sumida, MD, Third Department of Internal Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. E-mail: sumidaya{at}clin.medic.mie-u.ac.jp
Metabolically obese, normal-weight (MONW) subjects (BMI <25 kg/m2) are characterized by an excess (≥100 cm2 by abdominal computed tomography scanning) visceral fat area (VFA), insulin resistance, and hyperinsulinemia (1,2). The criteria for MONW subjects and the insulin resistance syndrome are very similar, and the pathophysiological events occurring in MONW subjects have recently been the focus of many investigators (1–4).
Several studies have reported the association of oxidative stress with insulin resistance and hyperinsulinemia in obese subjects (5,6). However, the degree of oxidative stress and its correlation with insulin resistance and insulin secretion have not yet been evaluated in MONW subjects.
The present study comprised 18 Japanese MONW (aged 34.7 ± 1.7 …
