The Relationship of Lipoprotein Lipase Activity and LDL size Is Dependent on Glucose Metabolism in an Elderly Population
The Hoorn Study
- Griët Bos, MSC1,
- Peter G. Scheffer, PHD2,
- Delfina Vieira, PHD3,
- Jacqueline M. Dekker, PHD1,
- Giel Nijpels, PHD1,
- Michaela Diamant, PHD2,
- Tom Teerlink, PHD2,
- Coen D.A. Stehouwer, PHD12,
- Lex M. Bouter, PHD1,
- Robert J. Heine, PHD12 and
- Hans Jansen, PHD3
- 1Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, the Netherlands
- 2Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, the Netherlands
- 3Departments of Internal Medicine and Clinical Chemistry, Erasmus MC, Rotterdam, the Netherlands
- Address correspondence and reprint requests to Griët Bos, MSc, Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands. E-mail: g.bos.emgo{at}med.vu.nl
Small LDL size is common in patients with type 2 diabetes and is associated with an increased risk of cardiovascular disease (1). LDL size is determined by various constituents of lipoprotein metabolism, such as lipoprotein lipase (LPL) and hepatic lipase (HL) activities, cholesteryl ester transfer protein (CETP), as well as triglyceride concentrations (2–4). Although abnormalities in LPL, HL, and CETP levels are associated with a diabetic lipoprotein profile, a relation to insulin resistance has been found only with lipase activities (5–7) but not with CETP (8,9). In this cross-sectional study, we investigated the relationship of LPL and HL activities and CETP mass with LDL size in 426 subjects with normal and impaired glucose metabolism or type 2 diabetes.
RESEARCH DESIGN AND METHODS
The Hoorn Study is a population-based cohort study of glucose metabolism and cardiovascular risk factors among 2,484 inhabitants of the municipality of Hoorn, which started in 1989. In 2000–2001, a follow-up was conducted in selected subjects then aged 60–87 years, as previously described (10). We invited all surviving subjects with type 2 diabetes (n = 176) and …
