Reduced Adiponectin Concentration in Women With Gestational Diabetes

A potential factor in progression to type 2 diabetes

  1. Ravi Retnakaran, MD12,
  2. Anthony J.G. Hanley, PHD12,
  3. Nuryt Raif, RD2,
  4. Philip W. Connelly, PHD3,
  5. Mathew Sermer, MD4 and
  6. Bernard Zinman, MD12
  1. 1Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
  2. 2Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
  3. 3Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
  4. 4Division of Obstetrics and Gynecology, Mount Sinai Hospital, Toronto, Ontario, Canada
  1. Address correspondence and reprint requests to Dr. Bernard Zinman, Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, 60 Murray St., Suite 5024, Toronto, Ontario, Canada, M5G 1X5. E-mail: zinman{at}mshri.on.ca

Adiponectin, a novel protein secreted exclusively by adipocytes, has emerged as an important potential mediator of the insulin resistance that is so characteristic of obesity, type 2 diabetes, and atherosclerotic cardiovascular disease (1,2). Consistent with the established inverse relationship between plasma adiponectin concentration and insulin resistance, hypoadiponectinemia has been documented in patients with each of these pathologic conditions (3–7). Moreover, in the Pima Indian population, low baseline adiponectin concentration predicts the subsequent development of insulin resistance (8), whereas conversely, elevated baseline adiponectin levels have been shown to be protective against the future development of type 2 diabetes (9). Taken together, these observations suggest that hypoadiponectinemia may be an important factor in the development of insulin resistance and the pathophysiology of type 2 diabetes. Gestational diabetes mellitus (GDM) identifies a population of young women at high risk of developing type 2 diabetes (10), representing an early stage in the natural history of the disease. Thus, we hypothesized that hypoadiponectinemia may be associated with GDM. The present study investigated the relationship between adiponectin and glucose tolerance in pregnancy.

RESEARCH DESIGN AND METHODS

The study design, protocol, and laboratory methods have been fully described previously (11). The study protocol was approved by the research ethics board at Mount Sinai Hospital, and all subjects gave written informed …

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