Regular Aerobic Exercise Training Improves Endothelium-Dependent Arterial Dilation in Patients With Impaired Fasting Glucose
- Xiang Guang-da, MD1 and
- Wang Yun-lin, MD2
- 1Department of Endocrinology, Guangzhou Command Wuhan General Hospital of the People’s Liberation Army, Wuluo Road 627, Wuhan 430070, Hubei Province, China
- 2Department of Gerontism, Tongji Hospital, Tongji Medical College, Huazhong Scientific University, Jiefang Road, Wuhan 430030, Hubei Province, China
- Address correspondence and reprint requests to Dr. Xiang Guang-da, Department of Endocrinology, Wuluo Rd. 627, Wuchang 430070, Wuhan, Hubei 430070, China. E-mail: guangda64{at}163.net
Vehkavaara et al. (1) demonstrated that impaired endothelium-dependent arterial dilation characterizes patients with impaired fasting glucose (IFG). The purpose of the study was to investigate the effects of exercise training on endothelium-dependent arterial dilation in subjects with IFG using noninvasive measurement of flow-mediated, endothelium-dependent dilation of the brachial artery.
RESEARCH DESIGN AND METHODS
The study group included 30 sedentary Chinese Han men with IFG between 48 and 74 years of age, mean age 63 ± 12 years. The diagnosis of IFG fulfilled the diagnostic criteria proposed by the American Diabetes Association. The subjects participated in a 6-month exercise training program. Of them, eight discontinued the study after 1 month of training. Additionally, 30 sedentary healthy men aged 46–76 years, mean age 65 ± 11 years, were selected as control subjects.
Subjects with IFG underwent a supervised orientation and thereafter performed …
