Predictive Value of Circulating Oxidized LDL for Cardiac Events in Type 2 Diabetic Patients With Coronary Artery Disease
- Kazunori Shimada, MD,
- Hiroshi Mokuno, PHD,
- Eriko Matsunaga, MD,
- Tetsuro Miyazaki, MD,
- Katsuhiko Sumiyoshi, BS,
- Atsumi Kume, MD,
- Katsumi Miyauchi, MD and
- Hiroyuki Daida, PHD
- From the Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan
- Address correspondence to Kazunori Shimada, MD, Department of Cardiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. E-mail: shimakaz{at}med.juntendo.ac.jp
Oxidized LDL (oxLDL) has been shown to play an important role in the initiation and development of atherosclerosis (1). Individuals with type 2 diabetes exhibit enhanced LDL oxidizability and accelerated atherosclerosis (2,3). Past studies demonstrated the association between LDL oxidation and atherosclerosis by “indirect” methods, such as lag times and propagation rates for LDL oxidation, and antibodies against oxLDL. Recently, some groups have developed “direct” methods for measuring circulating oxLDL (4–6). Indeed, several lines of evidence have demonstrated that the level of circulating oxLDL is significantly higher in patients with type 2 diabetes, is a marker for identifying patients …
