Diagnosing Insulin Resistance by Simple Quantitative Methods in Subjects With Normal Glucose Metabolism
Response to Ascaso et al.
- Rajaram J. Karne, MD,
- Hui Chen, MD and
- Michael J. Quon, MD, PHD
- From the Diabetes Unit, National Center for Complementary and Alternative Medicine (NCCAM), National Institutes of Health, Bethesda, Maryland
- Address correspondence to Michael J. Quon, MD, PhD, Chief, Diabetes Unit, NCCAM, NIH, 10 Center Dr., Building 10, Room 6C-205, Bethesda, MD 20892-1632. E-mail: quonm{at}nih.gov
Ascaso et al. (1) evaluated insulin sensitivity in 65 healthy subjects using minimal model analysis of an insulin-modified frequently sampled intravenous glucose tolerance test (FSIVGTT) to estimate the insulin sensitivity parameter derived from minimal model (SIMM) (2), as well as simple surrogates including fasting insulin, homeostasis model assessment (3), QUICKI (4), and the McAuley index (5). A statistically significant correlation was observed between SIMM and all of the other surrogate indexes examined. However, using SIMM as the reference method, the authors claim that the McAuley index has the best correlation with SI …
