Diagnosing Insulin Resistance by Simple Quantitative Methods in Subjects With Normal Glucose Metabolism
Response to Karne, Chen, and Quon
- Juan F. Ascaso, MD,
- Susana Pardo, MD,
- José T. Real, MD,
- Rosario I. Lorente, MD,
- Antonia Priego, MD and
- Rafael Carmena, MD
- From the Department of Medicine, University of Valencia, Valencia, Spain
- Address correspondence to Juan F. Ascasco, MD, University of Valencia, Dept. of Medicine, Blasco Ibanez 15, Valencia 46010, Spain. E-mail: ascaso{at}uv.es or juan.f.ascaso{at}uv.es
We thank Karne et al. for their comments (1) on our article (2). The ideal method to evaluate insulin resistance and insulin sensitivity, outside of the euglycemic-hyperinsulinemic clamp, has not yet been fully established. However, the minimal model, extensively used during the past decades, is considered a valuable surrogate of the clamp (3–5). The genetic factors involved in insulin sensitivity are better determined with the minimal model approach than with indirect methods based …
