Comparative Study of Prognostic Value for Coronary Disease Risk Between the U.K. Prospective Diabetes Study and Framingham Models
Response to Protopsaltis et al.
- Richard J. Stevens, PHD,1 and
- Rury Holman, FRCP1
- 1Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K
- Address correspondence to Dr. Richard Stevens, Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Oxford, OX3 7LJ U.K. E-mail: risk.engine{at}dtu.ox.ac.uk
The comparison by Protopsaltis et al. (1) of the Framingham risk equations and the U.K. Prospective Diabetes Study (UKPDS) risk engine as predictors of coronary risk in diabetes is of interest, as previous analyses have shown that the Framingham equations can underestimate absolute coronary heart disease (CHD) risk in diabetic subjects by a factor of 2 or more (2,3). The sensitivity and specificity analyses presented by the authors, however, are …
