The Human Insulin Analog Aspart Can Induce Insulin Allergy
- Xu JiXiong, MD,
- Liu Jianying, MD,
- Chang Yulan, MD and
- Chen Huixian, MD
- Department of Endocrinology, First Affiliated Hospital of JiangXi Medical College, NanChang, Jiangxi, China
- Address correspondence to Xu JiXiong, MD, First Affiliated Hospital of JiangXi Medical College, Department of Endocrinology, 17 N. Yongwaizheng St., Nanchang, JiangXi, 330006 China. E-mail: x2jo{at}163.com
The human insulin analog aspart is produced by recombinant technology that replaces the proline at position 28 on the β-chain of insulin with negatively charged aspartic acid. Insulin aspart exists as hexamers that rapidly dissociate into monomers and dimers after the subcutaneous injection (1); it appears that it has a reduced antigenicity. It has been confirmed to be less immunogenic for development of antibodies than human insulin (2). Several case reports indicated that the human insulin analog aspart does not cause insulin allergy and is a safe alternative in insulin allergy (3,4). But a case report showed that the patient developed cutaneous allergic reactions not only to human …
