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Hypoglycemic Coma in a Diabetic Patient on Peritoneal Dialysis due to Interference of Icodextrin Metabolites With Capillary Blood Glucose Measurements

  1. Emmanuel Disse, MD and
  2. Charles Thivolet, MD, PHD
  1. From the Department of Endocrinology and Diabetes, Hopital Edouard Herriot, Lyon, France
  1. Address correspondence to Pr. Charles Thivolet, Department of Endocrinology and Diabetes, Hopital Edouard Herriot, Place d’Arsonval, 69003 Lyon, France. E-mail: charles.thivolet{at}chu-lyon.fr

Continuous ambulatory peritoneal dialysis is used in about one-third of the diabetic population as an alternative to hemodialysis for end-stage renal disease (ESRD). Several case reports and articles (1–3) have alerted health professionals on the potential interference of dialysis fluid containing 7.5% icodextrin, a cornstarch-derived glucose polymer (Extraneal; Baxter Healthcare, Castlebar, Ireland), with some glucose reagent systems using a glucose dehydrogenase enzyme …

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