Effect of High-Dose Vitamin E on Insulin Resistance and Associated Parameters in Overweight Subjects
Response to Vale
- Patrick J. Manning, MMEDSC, FRACP,
- Wayne H.F. Sutherland, PHD and
- Robert J. Walker, MD, FRACP
- From the Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
- Address correspondence to Patrick J. Manning, MMEDSC, FRACP, University of Otago, Dunedin School of Medicine, Department of Medicine, 201 Great King St., Dunedin, New Zealand. E-mail: patrickmanning{at}healthotago.co.nz
We take issue with the points Vale (1) has raised. While it is established that vitamin E does not influence myeloperoxidase-catalyzed lipid peroxidation in vitro, this does not exclude possible benefits from vitamin E supplementation in vivo in subjects with increased myeloperoxidase activity and high risk of coronary heart disease. For example, supplementation with vitamin E reduced the risk of myocardial infarction, including sudden death in hemodialysis patients (2). Whether the antioxidant activity of vitamin E is responsible for this improved risk of coronary heart disease is unknown, and other effects of vitamin E may be implicated. As pointed out in our report, vitamin E …
