Postprandial Hyperglycemia Is a Better Predictor of the Progression of Diabetic Retinopathy Than HbA1c in Japanese Type 2 Diabetic Patients
- Toshihiko Shiraiwa, MD1,
- Hideaki Kaneto, MD, PHD1,
- Takeshi Miyatsuka, MD, PHD1,
- Ken Kato, MD1,
- Kaoru Yamamoto, MD1,
- Ayaha Kawashima, MD1,
- Tsutomu Kanda, MD, PHD2,
- Masaaki Suzuki, MD, PHD2,
- Eiichi Imano, MD, PHD2,
- Munehide Matsuhisa, MD, PHD1,
- Masatsugu Hori, MD, PHD1 and
- Yoshimitsu Yamasaki, MD, PHD1
- 1Department of Internal Medicine and Therapeutics (A8), Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
- 2Department of Gastroenterology and Metabolic Disease, Osaka Prefectural General Hospital, Sumiyoshi-ku, Osaka, Japan
- Address correspondence to Yoshimitsu Yamasaki, MD, PhD, Department of Internal Medicine and Therapeutics (A8), Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan. E-mail: yamasaki{at}medone.med.osaka-u.ac.jp
It is well known that postchallenge and postprandial hyperglycemia are related to the progression of diabetic macroangiopathy (1–6). However, there is little information regarding the association between diabetic microangiopathy and postprandial hyperglycemia in human subjects. In this study, we performed a follow-up study to elucidate the relationship between diabetic retinopathy and postprandial glycemia or insulinemia.
We recruited 151 Japanese patients with type 2 diabetes (74 men, aged 58.1 ± 10.2 years, and 77 women, aged 57.9 ± 9.2 years) who were admitted to Osaka Prefectural General Hospital between 1 January 1995 and 31 December 1999. The mean …
