Pancreatic Elastase-1 in Stools, a Marker of Exocrine Pancreas Function, Correlates With Both Residual β-Cell Secretion and Metabolic Control in Type 1 Diabetic Subjects
Response to Mueller et al.
- Franco Cavalot, MD1,
- Katia Bonomo, MD1,
- Elisa Fiora, MD1,
- Ezio Gaia, MD2 and
- Mariella Trovati, MD1
- 1Diabetes Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano (Turin), Italy
- 2Gastroenterology Unit, Department of Internal Medicine, San Luigi Gonzaga Hospital, Orbassano (Turin), Italy
- Address correspondence to Prof. Mariella Trovati, MD, Diabetes Unit, Department of Clinical and Biological Sciences of the University of Turin, San Luigi Gonzaga Hospital, 10043 Orbassano (Turin), Italy. E-mail: mariella.trovati{at}unito.it
We thank Mueller et al. (1) for their interest in our article (2), in which we demonstrated that type 1 diabetic patients present low fecal pancreatic elastase-1 (PE-1) and that PE-1 correlates with C-peptide, HbA1c (A1C), and diabetes duration. In 16 type 1 diabetic patients, they found that PE-1 concentrations were low compared with control subjects but did not correlate with A1C and diabetes duration.
Furthermore, Mueller et al. observed that patients on drugs interfering with the angiotensin system show a further reduction of PE-1. Since we did not mention treatment …
