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Initiation of Insulin Therapy in Patients With Type 2 Diabetes Failing Oral Therapy

Response to Mikhail and Cope and to Janka

  1. Philip Raskin, MD
  1. Department of Internal Medicine, Southwestern Medical Center at Dallas, University of Texas, Dallas, Texas
  1. Address correspondence to Dr. Philip Raskin, University of Texas, Southwestern Medical Center at Dallas, Department of Internal Medicine, 5323 Harry Hines Blvd., Dallas, TX 75235-8858. E-mail: philip.raskin{at}utsouthwestern.edu

In a recent editorial (1), Davidson commented on two studies (2,3) in which insulin initiation using a basal insulin analog was compared with either a human insulin premix or an analog insulin premix. These articles have prompted further correspondence concerning the design and results of these studies (4,5).

Mikhail and Cope (4) and Janka (5) commented that the greater HbA1c reduction observed in patients taking biphasic insulin aspart 70/30 (BIAsp 70/30), as compared with …

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