Type III Allergy to Insulin Detemir
- Patrice Darmon, MD1,
- Virginie Castera, MD1,
- Marie-Christine Koeppel, MD2,
- Cathy Petitjean, MD1 and
- Anne Dutour, MD, PHD1
- 1Department of Endocrinology, Hôpital Nord, Marseille, France
- 2Department of Dermatology, Hôpital Nord, Marseille, France
- Address correspondence to Dr. Patrice Darmon, Service d’Endocrinologie, des Maladies Métaboliques et de la Nutrition, CHU Nord, 13915 Marseille, France. E-mail: pdarmon{at}ap-hm.fr
Allergy to insulin has become rare with human recombinant insulin or its analogs, with an estimated incidence of <1%. The most common clinical situation is related to the type I allergic reaction in the Gell and Coombs classification and usually consists of a local wheal-and-flare eruption at injection site with induration, pruritus, and burning sensation that appear a few minutes after the injection and last for 1–2 h; this reaction is rarely systemic, with urticaria, angioedema, or anaphylactic shock. Insulin …
