Regression of Sight-Threatening Macular Edema in Type 2 Diabetes Following Treatment With the Anti–Tumor Necrosis Factor Monoclonal Antibody Infliximab
- Petros P. Sfikakis, MD1,
- Nikos Markomichelakis, MD2,
- George P. Theodossiadis, MD3,
- Vlassis Grigoropoulos, MD3,
- Nikos Katsilambros, MD1 and
- Panayiotis G. Theodossiadis, MD4
- 1First Department of Propedeutic Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
- 2Ocular Inflammation and Immunology Service, Gennimatas Hospital, Athens, Greece
- 3Department of Ophthalmology, Dynan Hospital, Athens, Greece
- 4Department of Ophthalmology, Athens University Medical School, Athens, Greece
- Address correspondence and reprint requests to P.P. Sfikakis, MD, 3, Amaryllidos Str, 15452, Athens, Greece. E-mail: psfikakis{at}med.uoa.gr
- BCVA, best corrected visual acuity
- DME, diabetic macular edema
- OCT, ocular coherence tomography
- TNF, tumor necrosis factor
Diabetic retinopathy and diabetic macular edema (DME) are leading causes of blindness in an increasing number of patients with diabetes (1). Reduction of visual aquity in DME results from accumulation of fluid produced from a rupture of the blood-retinal barrier into the inner nuclear layer of the retina (1,2). Although the etiology of DME is unclear, an altered local expression of the pleiotropic cytokine tumor necrosis factor (TNF) may play an important pathogenetic role (2–5). Standard treatment of clinically significant DME consisting of laser photocoagulation reduces the risk of vision loss in 60% of cases, but recurrences are common, even among those patients who achieve an initial response (1). Various pharmacological therapies are currently under study, including intavitreal triamcinolone injections (6) or high doses of nonsteroidal anti-inflammatory agents that lower retinal expression of TNF (7).
The monoclonal anti-TNF antibody Infliximab neutralizes TNF actions and has been used for inflammatory arthritic conditions and Crohn’s disease since 1998 with a favorable safety profile (8). Because of the limitations of current treatments for DME, and based on our recent findings indicating that Infliximab is an effective therapy for cystoid macular edema associated with uveitis (9–11), we decided to give Infliximab for sight-threatening refractory DME.
RESEARCH DESIGN AND METHODS
Four women, aged 52–76 years, with type 2 …
