Positive Correlation of Galanin With Glucose in Type 2 Diabetes
- Ioannis Legakis, MD1,
- Timos Mantzouridis, PHD2 and
- Theodoros Mountokalakis, MD3
- 1Department of Endocrinology, Henry Dynan Hospital, Athens, Greece
- 2Laboratory of Medical Biopathology, Medical School, Evgenidion Hospital, University of Athens, Athens, Greece
- 3Third Department of Internal Medicine, Sotiria Hospital, University of Athens, Athens, Greece
- Address correspondence to Dr. Ioannis Legakis, Department of Endocrinology, Henry Dynan Hospital, 27 Navarinou St., Athens 155 62, Greece. E-mail: ilegak{at}med.uoa.gr
Compelling literature (1) has been accumulated regarding the action of galanin as an incretin on insulin secretion. Although galanin inhibits glucose-stimulated insulin release in animals, no such effect has been documented in humans (2). Actually, galanin administration in humans has been shown to suppress the initial postprandial rise in plasma concentration of glucose and insulin (3) with unaltered glucose-stimulated insulin release (2). Nevertheless, basal plasma galanin levels have been shown to diverge with obesity and hormonal status.
We enrolled 21 patients with type 2 diabetes (HbA1c 7.8 ± 1.19%): 9 men (aged 54.6 ± 3.87 years, BMI 28.5 ± 1.6 …
