The Role of Platelet-Activating Factor in Pathogenesis of Type 1 Diabetes
- Betül Ersoy, MD1,
- Afig Hüseyinov2 and
- Şükran Darcan2
- 1Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Celal Bayar University School of Medicine, Manisa, Turkey
- 2Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Ege University School of Medicine, Izmir, Turkey
- Address correspondence to Dr. Betul Ersoy, MD, Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Celal Bayar University School of Medicine, Manisa, Turkey. E-mail: betul.ersoy{at}bayar.edu.tr
Platelet-activating factor (PAF) is a phospholipid mediator that exhibits diverse and potent effects on many cell types (1). PAF is a potent mediator of hypersensitivity and inflammatory reactions (2). Type 1 diabetes is caused by autoimmune destruction of the β-cells in the pancreas, which is initiated years before the clinical presentation of disease (3). In recent-onset type 1 diabetes and in animal models of autoimmune diabetes, a characteristic pathological finding in the islets of Langerhans is the accumulation of mononuclear cells and β-cell death (insulitis) (4,5). In this study, we investigated the role of PAF as an inflammatory mediator in pathogenesis of type 1 diabetes, …
