Is Atherosclerosis in Diabetes and Impaired Fasting Glucose Driven by Elevated LDL Cholesterol or by Decreased HDL Cholesterol?
Response to Drexel et al.
- Matthias B. Schulze, DRPH and
- Kurt Hoffmann, PHD
- From the Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
- Address correspondence to Matthias B. Schulze, German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Epidemiology, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany. E-mail: mschulze{at}mail.dife.de
In the report of Drexel et al. (1), an HDL-related cluster of lipid markers was significantly associated with risk of cardiovascular disease among coronary patients with type 2 diabetes, whereas an LDL-related cluster was not significantly associated. The authors conclude from their observation that “in today’s setting of effective LDL cholesterol lowering with statins, HDL cholesterol, triglycerides, and LDL particle diameter are the predominant lipid risk factors determining the fate of coronary patients with diabetes.”
Although Drexel et al. briefly discuss the issue …
