Two-Year Outcome of a Combination of Weight Loss Therapies for Type 2 Diabetes
- J. Bruce Redmon, MD,
- Kristell P. Reck, RD,
- Susan K. Raatz, PHD,
- Joyce E. Swanson, RD,
- Christine A. Kwong, RD,
- Hong Ji, MS,
- William Thomas, PHD and
- John P. Bantle, MD
- Division of Endocrinology and Diabetes, Department of Medicine, General Clinical Research Center, and the Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota
- Address correspondence and reprint requests to J. Bruce Redmon, MD, Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota, MMC 101, 420 Delaware St. SE, Minneapolis, MN 55455. E-mail: redmo001{at}umn.edu
Abstract
OBJECTIVE—To evaluate the effects over 2 years of a weight loss program combining several weight loss strategies on weight loss and diabetes control in overweight subjects with type 2 diabetes.
RESEARCH DESIGN AND METHODS—A total of 59 overweight or obese individuals with type 2 diabetes were randomly assigned to either a combination therapy weight loss program for 2 years (C therapy) or a standard therapy weight loss program for 1 year followed by a combination therapy weight loss program in the 2nd year (S/C therapy). C therapy combined the use of meal replacement products, repetitive intermittent low-calorie-diet weeks, and pharmacologic therapy with sibutramine. Outcome measures included changes in weight, glycemic control, plasma lipids, blood pressure, and body composition over 2 years.
RESULTS—A total of 48 participants (23 in the C therapy group and 25 in the S/C therapy group) completed 2 years of study. After 2 years, the C therapy group had weight loss of 4.6 ± 1.2 kg (P < 0.001) and a decrease in HbA1c of 0.5 ± 0.3% (P = 0.08) from baseline. At 2 years, the C therapy group had significant reductions in BMI, fat mass, lean body mass, and systolic blood pressure. The S/C therapy group showed changes in weight and HbA1c in year 2 of the study that were similar to those demonstrated by the C therapy group in year 1.
CONCLUSIONS—This combination weight loss program resulted in significant weight loss and improved diabetes control over a 2-year period in overweight subjects with type 2 diabetes.
Footnotes
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A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.
See accompanying editorial, p. 1526.
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- Accepted February 21, 2005.
- Received November 18, 2004.
- DIABETES CARE
