Metabolic Alterations in Middle-Aged and Elderly Lean Patients With Type 2 Diabetes

  1. Graydon S. Meneilly, MD1 and
  2. Dariush Elahi, PHD2
  1. 1Division of Geriatric Medicine, the Department of Medicine, University of British Columbia, Vancouver, British Colombia, Canada
  2. 2Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts
  1. Address correspondence and reprint requests to Graydon S. Meneilly, MD, Department of Medicine, Room 3300-950 West 10th Ave., Vancouver, BC, Canada, V5Z4E3. E-mail: meneilly{at}

Numerous studies (1–6) have systematically examined the metabolic alterations that occur in middle-aged patients with type 2 diabetes. These studies have found that when compared with age- and weight-matched control subjects, patients with type 2 diabetes have increased fasting hepatic glucose production, impaired glucose-induced release, and resistance to insulin-mediated glucose disposal. Diabetes is common in the elderly (7), but few studies (8–10) have examined the metabolic changes that occur in elderly subjects with diabetes. Recently, we compared metabolic changes in obese middle-aged and elderly control subjects and patients with diabetes (10). We now report our findings in lean middle-aged and elderly control subjects and patients with diabetes.


This study was conducted in middle-aged and elderly control …

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