Comparison of Clinical and Laboratory Characteristics Between Adult-Onset Type 1 Diabetes and Latent Autoimmune Diabetes in Adults
- Pedro Weslley Souza Rosário, MD,
- Janice Sepulveda Reis, MD,
- Ricardo Amim, MD,
- Tiago Alvarenga Fagundes, MD,
- Maria Regina Calsolari, MD,
- Saulo Cavalcanti Silva, MD and
- Saulo Purisch, MD
- From the Endocrinology Service, Santa Casa de Belo Horizonte, Minas Gerais, Brazil
- Address correspondence and reprint requests to Pedro Weslley Souza Rosário, Centro de Estudos e Pesquisa da Clinica de Endocrinologia e Metabologia (CEPCEM), Av. Francisco Sales, 1111, 5 andar Ala D, Santa Efigênia, CEP 30150-221, Belo Horizonte, MG, Brasil. E-mail: pedrorosario{at}globo.com
- GADA, GAD antibody
- ICA, islet cell antibody
- LADA, latent autoimmune diabetes in adults
- TPOA, anti-TPO antibody
Although they do not initially require insulin, diabetic adults presenting autoantibodies against β-cells (anti-GAD antibody [GADA] and anti–islet cell antibody [ICA]) more rapidly develop the need for insulinization, a fact characterizing latent autoimmune diabetes in adults (LADA) (1,2). Differences between LADA and type 2 diabetes (3–6) and between children and adults with type 1 diabetes (7) have been reported. In contrast, few studies are available comparing type 1 diabetes diagnosed during adulthood with LADA, with the results not being consistent (4,5,8). Therefore, the aim of the present study was to investigate clinical and laboratory parameters in patients with LADA compared with patients with adult-onset type 1 diabetes.
Research Design and Methods
Among the diabetic adults (age at diagnosis >35 years) seen at our service and investigated with GADA upon diagnosis (no routine ICA analysis was performed) (2), 54 patients with LADA (individuals not requiring insulin for at least 1 year after diagnosis and positive for GADA) (1,2,4,5) and …
