Plasma Interleukin-10 Concentration Is Positively Related to Insulin Sensitivity in Young Healthy Individuals
- Marek Straczkowski, MD,
- Irina Kowalska, MD,
- Agnieszka Nikolajuk, PHD,
- Agnieszka Krukowska, MD and
- Maria Gorska, MD
- 1Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
- Address correspondence and reprint requests to Marek Straczkowski, MD, Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, M.C. Sklodowskiej 24a, 15-276 Bialystok, Poland. E-mail: mstraczkowski{at}poczta.onet.pl
There is evidence linking insulin resistance with low-grade chronic inflammation (1). Proinflammatory cytokines, such as tumor necrosis factor-α and interleukin (IL)-6, might impair insulin action (2,3). Little is known about associations between insulin action and anti-inflammatory cytokines. IL-10 is a cytokine with potent anti-inflammatory properties (4). Recent studies provided evidence that IL-10 might exert some beneficial metabolic effects (5–7). So far, no data are available regarding an association between circulating IL-10 and insulin action in humans. The aim of the present study was to examine the relationship between plasma IL-10 concentration and whole-body insulin sensitivity in apparently healthy humans.
RESEARCH DESIGN AND METHODS
A total of 93 subjects, 55 men and 38 women, participated in the present study. All participants had no cardiovascular disease, hypertension, morbid obesity (BMI >40 kg/m2), infections, or any other serious medical problems. The mean age of the study group was 28.13 ± 8.37 years and the mean BMI 26.06 ± 4.79 kg/m2. Subjects underwent an oral glucose tolerance test and all had normal glucose tolerance according to World Health Organization criteria (fasting and postload glucose 5.04 ± 0.56 and 4.91 ± 1.29 mmol/l, respectively). All subjects were nonsmokers and were not taking any anti-inflammatory drugs …
