PRESERVE-β

Table 1—

Details of dose regimens

Dose level	Nateglinide (120-mg tablets or matching placebo)					Glyburide or matching placebo (number of tablets of 1.25-mg strength [a] and/or 2.5-mg strength [b])			Open-label metformin (500-mg tablets)		Total daily dose of nateglinide or glyburide and metformin (mg)
Dose level		Number of tablets before breakfast	Number of tablets before lunch	Number of tablets before dinner	Number of tablets before breakfast	Number of tablets before dinner	Number of tablets before breakfast	Number of tablets before dinner	Nateglinide or glyburide		Metformin
1	1	1	1	1a	—	—	1	360	1.25	500
2	1	1	1	1a	1a	—	1	360	2.5	500
3	1	1	1	2a	1a	1	1	360	3.75	1,000
4	1	1	1	2a	2a	1	1	360	5	1,000
5	1	1	1	1a, 1b	1b	1	2	360	6.25	1,500
6	1	1	1	2b	1b	1	2	360	7.5	1,500
7	1	1	1	2b	1a, 1b	2	2	360	8.75	2,000
8	1	1	1	2b	2b	2	2	360	10	2,000
0*	1 (60 mg)	1 (60 mg)	1 (60 mg)	1a	—	—	1	180	1.25	500
9†	1 (180 mg)	1 (180 mg)	1 (180 mg)	2 (5 mg)	1 (5 mg)	2	2	540	15	2,000

*
↵* Downward dose adjustment to nateglinide, 60 mg a.c.
†
↵† Rescue dose using 180-mg tablets of nateglinide (a.c.) or 15 mg of glyburide given in divided daily doses.

Diabetes Care