The Peroxisome Proliferator–Activated Receptor-γ2 P12A Polymorphism and Type 2 Diabetes in an Arab Population
- Salma M Wakil, PHD1,
- Khalid Al-Rubeaan, MD, FRCP(C)2,
- Osama Alsmadi, PHD1,
- Faiqa Imtiaz, PHD1,
- Pamela Carroll, BSC1,
- Mohammed Rajab, BSC1,
- Shaden Al-Katari, MD2,
- Mohammed Al-Katari, MD2 and
- Brian F. Meyer, PHD1
- 1Aragene Laboratory, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
- 2Diabetes Center, King Abdulaziz University Hospital, Riyadh, Saudi Arabia
- Address correspondence to Khalid Al-Rubeean, MD, FRCP(C), Diabetes Center, KAUH, Riyadh 18397, Saudi Arabia 11415. E-mail: krubean{at}ksu.edu.sa
The association of type 2 diabetes with the P12A polymorphism of the peroxisome proliferator–activated receptor gene (PPAR-γ2) has been established in several populations (1). However, no studies have thus far been reported for Arab populations. While many variants have been identified in this gene, the most prevalent and best studied is the P12A polymorphism. There is considerable interpopulation variance in the incidence of the risk allele (P12). This ranges in frequency from a high of 0.96–0.98 in populations including the Japanese, Chinese, and African Americans to 0.91 in …
