Decreased High–Molecular Weight Adiponectin–to–Total Adiponectin Ratio in Sera Is Associated With Insulin Resistance in Japanese Metabolically Obese, Normal-Weight Men With Normal Glucose Tolerance
- Akira Katsuki, MD1,
- Mina Suematsu, MD1,
- Esteban C. Gabazza, MD2,
- Shuichi Murashima, MD3,
- Kaname Nakatani, MD4,
- Kenji Togashi, PHD5,
- Yutaka Yano, MD1 and
- Yashuhiro Sumida, MD1
- 1Division of Diabetology and Endocrinology, Department of Internal Medicine, Mie University School of Medicine, Mie, Japan
- 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mie University School of Medicine, Mie, Japan
- 3Department of Radiology, Mie University School of Medicine, Mie, Japan
- 4Department of Laboratory Medicine, Mie University School of Medicine, Mie, Japan
- 5Department of Health and Physical Education, Mie University School of Education, Mie, Japan
- Address correspondence to Y. Sumida, MD, Department of Internal Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan. E-mail: sumidaya{at}clin.medic.mie-u.ac.jp
Adiponectin is a key regulator of insulin resistance. Recent studies on multimer formation in human blood have demonstrated that high–molecular weight (HMW) adiponectin is the active form of the protein (1–3). Recently, Hara et al. (3) demonstrated that the ratio of HMW adiponectin to total adiponetin (HMWR) in systemic circulation is useful for the prediction of insulin resistance and metabolic syndrome.
Metabolically obese, normal-weight (MONW) subjects (BMI <25 kg/m2) are characterized by excess visceral fat area (VFA; ≥100 cm2 by abdominal computed tomography scanning) and insulin resistance (4–6). In addition, we previously demonstrated that the …
