Age and Sex May Significantly Interact With Diabetes on the Risks of Lower-Extremity Amputation and Peripheral Revascularization Procedures
Evidence from a cohort of a half-million diabetic patients
Article Figures & Tables
Figures
- Figure 1—
Kaplan-Meier survival curves for LEA (A) and PRP (B).
Tables
- Table 1—
Overall and age- and sex-specific incidence densities and relative hazards of nontraumatic LEA (ICD-9: 84.1 and 84.10–84.18) in the diabetic and control groups
Variables* Control group Diabetic group Adjusted HR (95% CI)‡ in association with diabetic group Patients (n) No. of events ID (per 100,000 patient-years) (95% CI)† Patients (n) No. of events ID (per 100,000 patient-years) (95% CI)† Men (years of age) <35 7,333 0 0 7,332 35 86.8 (58.1–115.6) NA§ 35–44 25,017 13 11.2 (5.1–17.3) 25,010 232 169.6 (147.8–191.4) 14.12 (8.07–24.70) 45–54 47,114 35 15.6 (10.4–20.8) 47,078 724 283.1 (262.5–303.7) 17.40 (12.39–24.43) 55–64 63,512 105 36.6 (29.6–43.7) 63,463 1,538 460.5 (437.4–483.5) 12.44 (10.21–15.17) 65–74 69,768 220 64.3 (55.8–72.8) 69,701 1,840 526.9 (502.9–551.0) 8.30 (7.21–9.55) 75–84 20,541 109 121.8 (98.9–144.6) 20,511 574 635.7 (583.7–687.7) 5.40 (4.39–6.64) >84 1,369 3 62.3 (−8.2 to 132.8) 1,368 29 585.2 (372.2–798.2) 10.56 (3.20–34.89) Total 234,654 485 44.4 (40.5–48.4) 234,463 4,972 410.3 (398.9–421.7) 9.22 (8.39–10.12) Women (years of age) <35 7,830 1 3.2 (−3.1 to 9.4) 7,830 31 71.0 (46.0–96.0) 22.17 (3.02–162.85) 35–44 19,315 6 6.5 (1.3–11.8) 19,310 148 137.0 (115.0–159.1) 19.82 (8.76–44.86) 45–54 49,469 15 6.4 (3.2–9.6) 49,450 512 185.5 (169.4–201.6) 27.92 (16.71–46.66) 55–64 83,549 73 18.5 (14.3–22.7) 83,525 1,288 282.3 (266.9–297.7) 15.10 (11.91–19.15) 65–74 77,409 133 35.0 (29.0–40.9) 77,364 1,747 436.6 (416.1–457.1) 12.44 (10.42–14.85) 75–84 25,992 99 85.7 (68.8–102.6) 25,965 697 587.9 (544.2–631.5) 6.93 (5.60–8.58) >84 2,024 11 149.6 (61.2–238.0) 2,016 48 644.5 (462.2–826.9) 4.25 (2.20–8.24) Total 265,588 338 26.9 (24.0–29.8) 265,460 4,471 317.0 (307.0–326.3) 11.67 (10.44–13.05) - *
↵* Inconsistency between total population and population summed for individual variables was due to missing information.
- †
↵† Based on Poisson assumption.
- ‡
↵‡ Based on Cox proportional hazard regression with adjustment for age, sex, geographic area, and urbanization status.
- §
↵§ Not applicable (NA) due to no event of clinical end points for the control group <35 years of age. ID, incidence density.
- *
- Table 2—
Overall and age- and sex-specific incidence density and relative hazards of nontraumatic PRP (ICD-9: 39.25, 39.29, and 39.59) in the diabetic and control groups
Variables* Control group Diabetic group Adjusted HR (95% CI)‡ in association with diabetic group Patients (n) No. of events ID (per 100,000 patient-years) (95% CI)† Patients (n) No. of events ID (per 100,000 patient-years) (95% CI)† Men (years of age) <35 7,333 2 7.0 (−2.7 to 16.7) 7,333 8 19.8 (6.1–33.5) 2.71 (0.57–12.88) 35–44 25,017 2 1.7 (−0.677 to 4.1) 25,018 41 29.9 (20.7–39.0) 15.68 (3.80–65.24) 45–54 47,114 23 10.3 (6.1–14.4) 47,112 146 56.7 (47.5–65.9) 3.99 (3.11–5.11) 55–64 63,511 70 24.4 (18.7–30.2) 63,502 429 127.4 (115.4–139.5) 5.05 (3.91–6.52) 65–74 69,769 196 57.3 (49.3–65.3) 69,749 629 178.8 (164.9–192.8) 3.06 (2.60–3.60) 75–84 20,542 48 53.6 (38.4–68.7) 20,538 146 160.1 (134.2–186.1) 3.03 (2.18–4.22) >84 1,369 1 20.8 (−19.97 to 61.5) 1,369 5 99.9 (12.3–187.5) 5.51 (0.63–47.89) Total 234,655 342 31.3 (28.0–34.6) 234,722 1,405 115.2 (109.1–121.2) 3.56 (3.18–4.03) Women (years of age) <35 7,830 0 0 7,830 11 25.2 (10.3–40.1) NA§ 35–44 19,315 5 5.5 (0.7–10.2) 19,312 36 33.2 (22.4–44.1) 6.00 (2.34–15.22) 45–54 49,469 13 5.5 (2.5–8.5) 49,466 138 49.8 (41.5–58.2) 8.72 (4.93–15.41) 55–64 83,549 75 19.0 (14.7–23.3) 83,545 367 80.1 (71.9–88.2) 3.99 (3.11–5.11) 65–74 77,411 129 33.9 (28.1–39.8) 77,406 528 131.0 (119.9–142.2) 3.82 (3.14–4.64) 75–84 25,993 45 39.0 (27.6–50.3) 25,990 130 108.5 (89.9–127.2) 2.81 (1.99–3.96) >84 2,024 2 27.1 (−10.57 to 64.7) 2,024 10 132.5 (50.4–214.7) 4.61 (0.99–21.50) Total 265,591 269 21.4 (18.9–24.0) 265,629 1,220 86.0 (81.2–90.9) 3.92 (3.43–4.47) - *
↵* Inconsistency between total population and population summed for individual variables was due to missing information.
- †
↵† Based on Poisson assumption.
- ‡
↵‡ Based on Cox proportional hazard regression with adjustment for age, sex, geographic area, and urbanization status.
- §
↵§ Not applicable (NA) due to no event of clinical end points for the control group <35 years of age. ID, incidence density.
- *
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