Lifestyle Intervention Is Associated With Lower Prevalence of Urinary Incontinence

The Diabetes Prevention Program

  1. Jeanette S. Brown, MD,
  2. Rena Wing, PHD,
  3. Elizabeth Barrett-Connor, MD,
  4. Leroy M. Nyberg, MD, PHD,
  5. John W. Kusek, PHD,
  6. Trevor J. Orchard, MD,
  7. Yong Ma, MS,
  8. Eric Vittinghoff, PHD, MPH,
  9. Alka M. Kanaya, MD and
  10. for the Diabetes Prevention Program Research Group
  1. Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, Rockville, Maryland
  1. Address correspondence and reprint requests to Jeanette S. Brown, MD, Diabetes Prevention Program Research Group, The Biostatistics Center, George Washington University, 6110 Executive Blvd., Suite 750, Rockville, MD 20852. E-mail: dppmail{at}biostat.bsc.gwu.edu

Abstract

OBJECTIVE—Diabetes is associated with increased urinary incontinence risk. Weight loss improves incontinence, but exercise may worsen this condition. We examined whether an intensive lifestyle intervention or metformin therapy among overweight pre-diabetic women was associated with a lower prevalence of incontinence.

RESEARCH DESIGN AND METHODS—We analyzed data from the Diabetes Prevention Program, a randomized controlled trial in 27 U.S. centers. Of the 1,957 women included in this analysis, 660 (34%) were randomized to intensive lifestyle therapy, 636 (32%) to metformin, and 661 (34%) to placebo with standard lifestyle advice. The main outcome measure was incontinence symptoms by frequency and type by a validated questionnaire completed at the end-of-trial visit (mean 2.9 years).

RESULTS—The prevalence of total (stress or urge) weekly incontinence was lower among women in the intensive lifestyle group (38.3%) than those randomized to metformin (48.1%) or placebo (45.7%). This difference was most apparent among women with stress incontinence (31.3% for intensive lifestyle group vs. 39.7% for metformin vs. 36.7% for placebo, P = 0.006). Changes in weight accounted for most of the protective effect of the intensive lifestyle intervention on stress incontinence.

CONCLUSIONS—Less-frequent urinary incontinence may be a powerful motivator for women to choose lifestyle modification to prevent diabetes.

Footnotes

  • A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

    • Accepted November 14, 2005.
    • Received September 21, 2005.
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