Soluble Tumor Necrosis Factor Receptor 1 Is Strongly and Independently Associated With Serum Homocysteine in Nonobese Japanese Type 2 Diabetic Patients
- Ataru Taniguchi, MD1,
- Mitsuo Fukushima, MD2,
- Yoshikatsu Nakai, MD3,
- Minako Ohgushi, MD1,
- Akira Kuroe, MD1,
- Michihiro Ohya, MD1 and
- Yutaka Seino, MD1
- 1Division of Diabetes and Clinical Nutrition, Kansai-Denryoku Hospital, Osaka, Japan
- 2Department of Health Informatics Research, Translational Research Informatics Center, Kobe, Japan
- 3Karasuma-Nakai Clinic, Kyoto, Japan
- Address correspondence to Ataru Taniguchi, MD, Division of Diabetes and Clinical Nutrition, Kansai-Denryoku Hospital, 2-1-7 Fukushima, Fukushima-ku, Osaka City, Osaka 553-0003, Japan. E-mail: taniguchi.ataru{at}a5.kepco.co.jp
The major clinical consequence of type 2 diabetes is mortality and morbidity from atherosclerotic vascular disease. With regards to the risk factors responsible for the evolution of atherosclerosis, Bierman (1) estimated that typical risk factors, including smoking, cholesterol, and blood pressure, can account for no more than 30% of excess cardiovascular risk factors in diabetic patients. Thus, other factors seem to play a key role in the progression of atherosclerosis in diabetes.
One potential factor is homocysteine. Homocysteine has been shown …
