The Biogun
A novel way of eradicating methicillin-resistant Staphylococcus aureus colonization in diabetic foot ulcers
- Cuong Nguyen Dang, MCRP1,
- Ramzana Anwar, DPODM2,
- Gwen Thomas, DPODM2,
- Yemparala D.M. Prasad, MRCP1,
- Andrew J.M. Boulton, MD1 and
- Rayaz A. Malik, MD, PHD1
- 1University Department of Medicine, Manchester Royal Infirmary, Manchester, U.K
- 2Department of Podiatry, Manchester Foot Hospital, Manchester, U.K
- Address correspondence to Dr. C.N. Dang, c/o Professor A.J.M. Boulton, University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, U.K. E-mail: cndang{at}yahoo.com
Methicillin-resistant Staphylococcus aureus (MRSA) is an ever-increasing problem facing the health service in the U.K. There is a need to develop new methods of combating MRSA. In the Manchester diabetic foot clinic, the prevalence of MRSA is ∼40% of staphylococcal cultures. MRSA has been demonstrated to double the foot ulcer healing time (1). While the pathogenetic relevance of MRSA colonization remains debatable, MRSA even in clinically noninfected ulcers may take >6 months to disappear (2). The Dentron Biogun has been shown to ionize molecular oxygen and generate superoxide …
