Regression of Pancreatic Diabetes in Chronic Hereditary Pancreatitis
- Holm H. Uhlig, MD, DPHIL1,
- Angela Galler, MD1,
- Volker Keim, MD2,
- Joachim Mössner, MD2,
- Wieland Kiess, MD1,
- Karel Caca, MD23 and
- Niels Teich, MD2
- 1Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
- 2Department of Internal Medicine II, University of Leipzig, Leipzig, Germany
- 3Department of Internal Medicine I, Klinikum, Ludwigsburg, Germany
- Address correspondence to Niels Teich, Internal Medicine II, University of Leipzig, D-04103 Leipzig, Germany. E-mail: niels.teich{at}medizin.uni-leipzig.de
Pancreatic diabetes is believed to be an irreversible sign of progressive pancreatic failure (1). We report here on a girl with chronic hereditary pancreatitis and the R122H-mutation of the cationic trypsinogen gene (2), in whom pancreatic diabetes regressed in the course of the disease.
The girl initially presented at 6.3 years of age with acute pancreatitis. Episodes of diarrhea occurred shortly after initial presentation. The cholecystokinin-secretin stimulation test revealed global exocrine insufficiency. Oral pancreatic enzyme supplementation was initiated with porcine pancreatic extracts. Until the …
