Case Report of Klinefelter’s Syndrome With Severe Diabetes, Dyslipidemia, and Stroke
The effect of pioglitazone and other anti-inflammatory agents on interleukin-6 and -8, tumor necrosis factor-α, and C-reactive protein
- Issei Yoshiuchi, MD, PHD13,
- Naoto Itoh, MD, PHD1,
- Misa Nakano, MD, PHD2,
- Chikao Tatsumi, MD, PHD2,
- Kenji Yokoyama, MD, PHD1 and
- Tatsuo Matsuyama, MD, PHD1
- 1Department of Internal Medicine and Diabetes Center, Toyonaka Municipal Hospital, Osaka, Japan
- 2Department of Neurology, Toyonaka Municipal Hospital, Osaka, Japan
- 3Department of Internal Medicine and Diabetes Mellitus, Yoshiuchi Medical Diabetes Institute, Hyogo, Japan
- Address correspondence to Issei Yoshiuchi, MD, PhD, Department of Internal Medicine and Diabetes Mellitus, Yoshiuchi Medical Diabetes Institute, 30-15 Asahigaoka, Ashiya, Hyogo 659-0012, Japan. E-mail: yoshiuchi{at}m9.dion.ne.jp
Klinefelter’s syndrome is a sex chromosomal aberration of male infertility. Most diabetes of this syndrome shows insulin resistance. Chronic proinflammation is involved in the pathogenesis of diabetes, and cytokines play a role in insulin resistance (1,2,3). Interleukin (IL)-8 is a cytokine secreted by monocytes and endothelial cells (6). IL-6 is associated with insulin resistance and is an inducer of C-reactive protein (CRP) (1,2,7). IL-8, IL-6, and CRP are higher in diabetes (1,2,3,4,5). We report a 30-year-old …
