The Effect of Glucose Variability on the Risk of Microvascular Complications in Type 1 Diabetes
Response to Kilpatrick et al. and Bolli
- The Diabetes Research in Children Network (DirecNet) Study Group
- Address correspondence to Darrell Wilson, MD, c/o DirecNet Coordinating Center, Jaeb Center for Health Research, 15310 Amberly Dr., Suite 350, Tampa, FL 33647. E-mail: direcnet{at}jaeb.org
The article by Kilpatrick et al. (1) used data from the Diabetes Control and Complication Trial to investigate the relationship between glycemic variability and the subsequent development of diabetes complications. They report that glucose variability, as measured by a quarterly eight-point glucose profile (excluding the 3 a.m. value because of limited data), was not associated with development or progression of retinopathy or nephropathy. An accompanying editorial by Bolli (2) highlights the potential clinical impact of this finding, stating that “the instant …
