Serum Levels of Adipokine Retinol-Binding Protein-4 in Relation to Renal Function

  1. Michaela Ziegelmeier, MS1,
  2. Anette Bachmann, MD1,
  3. Jeannette Seeger, MS1,
  4. Ulrike Lossner, BS1,
  5. Jürgen Kratzsch, PHD2,
  6. Matthias Blüher, MD13,
  7. Michael Stumvoll, MD13 and
  8. Mathias Fasshauer, MD13
  1. 1Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
  2. 2Institute of Laboratory Medicine, University of Leipzig, Leipzig, Germany
  3. 3Interdisciplinary Center for Clinical Research Leipzig, Leipzig, Germany
  1. Address correspondence and reprint requests to Mathias Fasshauer, MD, Ph.-Rosenthal-Str. 27, 04103 Leipzig, Germany. E-mail: mathias.fasshauer{at}medizin.uni-leipzig.de

Abstract

OBJECTIVE—Retinol-binding protein (RBP)-4 was recently identified as an adipokine that induces insulin resistance. In the current study, we investigated RBP-4 serum levels in diabetic and nondiabetic patients on chronic hemodialysis (CD) compared with control subjects with a glomerular filtration rate >50 ml/min. The majority of the diabetic subjects used oral hypoglycemic agents or insulin.

RESEARCH DESIGN AND METHODS—RBP-4 was determined by enzyme-linked immunosorbent assay in control subjects (n = 59) and CD patients (n = 58) and correlated with clinical and biochemical measures of renal function, glucose and lipid metabolism, and inflammation in both groups.

RESULTS—Mean serum RBP-4 levels were almost fourfold higher in CD patients (102 ± 30 mg/l) compared with control subjects (28 ± 8 mg/l). Furthermore, serum creatinine independently predicted RBP-4 concentrations in multiple regression analyses in both control subjects and CD patients. In addition, C-reactive protein and systolic blood pressure independently and negatively correlated with RBP-4 serum concentrations in CD patients but not control subjects. In contrast, markers of glucose and lipid metabolism were not independently related to serum RBP-4 in control subjects or CD patients.

CONCLUSIONS—We show that markers of renal function are independently related to serum RBP-4 levels.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 13 July 2007. DOI: 10.2337/dc07-0275.

    M.Z. and A.B. contributed equally to this work.

    A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted July 9, 2007.
    • Received February 9, 2007.
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  1. Published online before print July 13, 2007, doi: 10.2337/dc07-0275 Diabetes Care October 2007 vol. 30 no. 10 2588-2592
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