Carotid Intima-Media Thickness in Pediatric Type 1 Diabetic Patients

  1. Rocio Rabago Rodriguez, MD1,
  2. Rita A. Gómez-Díaz, MD2,
  3. Janet Tanus Haj, MD3,
  4. Francisco Jose Avelar Garnica, MD3,
  5. Eleazar Ramirez Soriano, MD1,
  6. Elisa Nishimura Meguro, MD1,
  7. Carlos A. Aguilar-Salinas, MD4 and
  8. Niels H. Wacher, MD, PHD2
  1. 1Servicio de Endocrinología, UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico
  2. 2Unidad de Investigación Médica en Epidemiología Clínica, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico
  3. 3Servicio de Radiodiagnóstico, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico
  4. 4Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico
  1. Address correspondence and reprint requests to Rita Angélica Gómez-Díaz, Unidad de Investigación Médica en Epidemiología Clínica, UMAE Hospital de Especialidades, CMN-SXXI, IMSS, Av. Cuauhtémoc #330, Col. Doctores, Deleg. Cuauhtémoc, 06725 México, D.F., México. E-mail: ritagomezdiaz{at}netscape.net

Abstract

OBJECTIVE—To compare the carotid artery intima-media thickness in Hispanic pediatric type 1 diabetic patients against that in healthy control subjects matched for age, sex, height, and BMI.

RESEARCH DESIGN AND METHODS—The evaluation consisted of anthropometric measurements, biochemical parameters, and a carotid Doppler and real-time ultrasound, in which carotid artery intima-media thickness (cIMT), peak systolic velocity, and end diastolic velocity were measured using standardized procedures.

RESULTS—A total of 52 diabetic patients and 47 control subjects were included. No significant differences existed in the characteristics between case and control subjects (mean age 11.8 ± 3.1 vs. 11.8 ± 2.8 years, weight 42.2 ± 15.3 vs. 44.2 ± 14.4 kg, height 1.45 ± 0.15 vs. 1.47 ± 0.15 m, BMI 19.3 ± 3.2 vs. 19.9 ± 4.4 kg/m2, systolic blood pressure 99.1 ± 9.9 vs. 99.6 ± 9 mmHg, and diastolic blood pressure 63 ± 6.4 vs. 62.0 ± 5.7 mmHg, respectively). The mean duration of diabetes was 4.8 ± 3.2 years (range 6–144 months), and the mean A1C was 8.6 ± 1.6%. A significantly higher cIMT was found in the patients with type 1 diabetes (0.463 ± 0.04 vs. 0.441 ± 0.04 mm; P = 0.001). In contrast, both peak systolic velocity (107.1 ± 22.8 vs. 119.3 ± 19.2, P < 0.005) and end diastolic velocity (28.4 ± 6.0 vs. 33.0 ± 7.0, P < 0.001) were higher in the control subjects.

CONCLUSIONS—Type 1 diabetes is associated with higher cIMT and decreased flow velocities in a Hispanic pediatric population.

Footnotes

  • Published ahead of print at http://care.diabetesjournals.org on 20 July 2007. DOI: 10.2337/dc07-0922.

    A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted July 12, 2007.
    • Received May 14, 2007.
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  1. Diabetes Care vol. 30 no. 10 2599-2602
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