Association Between Urinary Albumin Excretion and Plasma 5-Hydroxyindole-3-Acetic Acid Concentration in Men With Type 2 Diabetes
- Michiaki Fukui, MD1,
- Hiroyuki Ose, MD1,
- Goji Hasegawa, MD1,
- Toshikazu Yoshikawa, MD2 and
- Naoto Nakamura, MD1
- 1Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyto, Japan
- 2Department of Inflammation and Immunology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
- Address correspondence and reprint requests to Michiaki Fukui, MD, Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. E-mail: sayarinapm{at}hotmail.com
- 5-HIAA, 5-hydroxyindole-3-acetic acid
- 5-HT, 5-hydroxytryptamine, IMT, intima-media thickness
- PWV, pulse wave velocity
- UAE, urinary albumin excretion
Serotonin (5-hydroxytryptamine [5-HT]) mediates vasoconstriction and induces the activation of platelets, which may promote atherosclerosis. Plasma 5-HT concentrations have been reported to be high in diabetic patients (1,2); this may be one of the underlying mechanisms of diabetes complications. The 5-HT2A receptor has been identified in glomerular mesangial cells (3), suggesting involvement of 5-HT in the development of diabetic nephropathy through proliferation and matrix sysnthesis in mesangial lesions. Male sex is an independent risk factor for cardiovascular disease (4). Moreover, elevated urinary albumin excretion (UAE) has been reported to be associated with increased risk of cardiovascular mortality (5). Few studies have examined the association between plasma 5-HT concentration and atherosclerosis (6). To our knowledge, a relationship between plasma 5-HT concentration and degree of UAE has never been explored in men with type 2 diabetes. In this study, we evaluated the relationships between plasma 5-hydroxyindole-3-acetic acid (5-HIAA), a derivative end product of 5-HT, concentration and degree of UAE, and markers of subclinical atherosclerosis, such as pulse wave velocity (PWV), ankle-brachial index (ABI), carotid intima-media thickness (IMT), or plaque score in men with type 2 diabetes.
RESEARCH DESIGN AND METHODS—
The relationships of plasma 5-HIAA concentrations with degree of UAE and major cardiovascular risk factors were investigated in 205 consecutive men with type 2 diabetes recruited from the outpatient clinic at the Kyoto Prefectural University of Medicine (Kyoto, Japan). Additionally, the relationships between plasma …
