Elevated Plasma Adiponectin and Leptin Levels in Sisters With Genetically Defective Insulin Receptors
- Yoshiyuki Hattori, MD, PHD,
- Noriko Hirama, MD,
- Kunihiro Suzuki, MD,
- Sachiko Hattori, MD, PHD and
- Kikuo Kasai, MD, PHD
- Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Japan
- Address correspondence to Yoshiyuki Hattori, MD, PhD, Department of Endocrinology and Metabolism, Dokkyo University, Mibu, Tochigi 321-0293, Japan. E-mail: yhattori{at}dokkyomed.ac.jp
Circulating levels of adiponectin have been shown to inversely correlate with insulin sensitivity. Interestingly, elevated adiponectin levels have been observed following treatment with thiazolidinediones. It has recently been reported (1) that paradoxical hyperadiponectinemia is observed in patients with mutations, leading to a loss of insulin receptor function. Here, we evaluated circulating levels of adiponectin and leptin following treatment with pioglitazone in two sisters referred for evaluation of hirsutism who were found to have insulin resistance secondary to an insulin receptor mutation.
A 15-year-old Japanese female patient, the younger of the two sisters, has been amenorrheic since menarche at age 12 years. …
