Intrauterine Growth Retardation, Insulin Resistance, and Nonalcoholic Fatty Liver Disease in Children
Response to Nobili et al.
- Abigail Fraser, MPH1,
- Shah Ebrahim, DM2,
- Yoav Ben-Shlomo, PHD1,
- George Davey Smith, DSC1 and
- Debbie A. Lawlor, PHD1
- 1Social Medicine Department, University of Bristol, Bristol, U.K
- 2Epidemiology and Population Health Department, London School of Hygiene and Tropical Medicine, London, U.K
- Address correspondence to Abigail Fraser, Social Medicine Department, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, U.K. E-mail: abigail.fraser{at}bristol.ac.uk
We read with interest the article by Nobili et al. (1), who reported results of a case-control study that demonstrated an association between intrauterine growth retardation (defined as small for gestational age [SGA]) and pediatric nonalcoholic streatohepatitis (nonalcoholic fatty liver disease [NAFLD]).
Nobili et al. (1) compared children with NAFLD with hospital control subjects. The choice of control subjects may result in an underestimate of the association between SGA and NAFLD if hospitalized children …
